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The information contained in this section of the site is intended for US healthcare professionals only. Please click the appropriate link below.

AK treatment designed
with you in mind

Pay as little as $25
for your KLISYRI® prescription
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Not actual patients. Results may vary.

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Designed to give you complete clearance

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KLISYRI® is a novel treatment for actinic keratosis (AK)

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KLISYRI® was studied in the largest AK clinical trial program of its kind*

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In these studies, 4x to 9x more KLISYRI® patients achieved complete 100% clearance than did placebo patients

*

The largest pivotal clinical trial program of an AK topical prescription treatment.

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Designed to meet your lifestyle needs

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New 5-day KLISYRI® is the shortest topical prescription treatment available for AK today. In clinical studies, 99% of patients stayed on KLISYRI® treatment for the full 5 days. No allergic reactions to the sun’s rays occurred in healthy patients who were using KLISYRI®†

Clinical studies in healthy subjects demonstrated KLISYRI® did not cause contact sensitization, phototoxic skin reactions, or photoallergic skin reactions.

Skin reactions with KLISYRI® were mostly mild to moderate

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In clinical trials, the most common side effects with KLISYRI® were local skin reactions, including itching and pain in the treatment area

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In these clinical trials, fewer than 1 in 10 patients had severe local skin reactions

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Local skin reactions can also be severe in treatment with KLISYRI®

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Call your healthcare provider if you develop any local skin reactions, including redness, flaking or scaling, crusting, or swelling that is more severe, or if you get blisters, peeling, pus, ulcers, or breakdown of your skin

Skin reactions to KLISYRI® treatment

MildFace
Skin picture, mild day 1
Skin picture, mild day 8
Skin picture, mild day 29
Day 1Day 8Day 29
ModerateFace
Skin picture, moderate day 1
Skin picture, moderate day 8
Skin picture, moderate day 29
Day 1Day 8Day 29
SevereScalp
Skin picture, severe day 1
Skin picture, severe day 8
Skin picture, severe day 29
Day 1Day 8Day 29
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In these studies, a total of 702 patients were monitored for development of skin reactions on day 8 following 5-day treatment with KLISYRI®, and then on days 15, 29, and 57. Skin reactions peaked at day 8 and resolved by day 29

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KLISYRI® is convenient to use

Available in convenient, disposable, single-use packs

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Do not use more KLISYRI® than you need to cover the treatment area

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Using too much KLISYRI®, or using it too often, or for too long can increase your chances of having a severe skin reaction or other side effects

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Do not get KLISYRI® in, around, or near your eyes

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Do not touch your eyes while you are applying KLISYRI®

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Do not get KLISYRI® in, around, or near your mouth or lips

Please see additional information in the How should I use KLISYRI®? section below

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Designed to make treatment affordable

Save on your prescription through Almirall Advantage

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If you have commercial (nongovernment) coverage, you may be able to pay as little as $25 for your KLISYRI® prescription

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Take advantage of the KLISYRI®
Comprehensive Specialty Pharmacy Network

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Save on your KLISYRI® prescription costs through a licensed pharmacy that can ship directly to you

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Access the KLISYRI® co-pay card

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Eligible patients with commercial (nongovernment) insurance only. Terms and conditions may apply.

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Designed to support your treatment needs

Download helpful information about AK and treatment with KLISYRI®, including how to apply.

AK: actinic keratosis.

Important Safety Information

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Important: KLISYRI is for use on the skin only (topical). Do not use KLISYRI in, around, or near your eyes, mouth or lips.

What is KLISYRI?

KLISYRI is a prescription medicine used on the skin to treat actinic keratosis on the face or scalp.
It is not known if KLISYRI is safe and effective in children less than 18 years of age.

Before using KLISYRI, tell your healthcare provider about all of your medical conditions, including if you:

  • are being treated or have been treated for actinic keratosis with any other medicine, procedure, or surgery. You should not use KLISYRI until your skin has healed from other treatments.
  • have other skin problems in the treatment area.
  • are pregnant or plan to become pregnant. It is not known if KLISYRI can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if KLISYRI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with KLISYRI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

How should I use KLISYRI?

  • Use KLISYRI as your healthcare provider tells you to. KLISYRI is for skin use only.
  • Apply KLISYRI to evenly cover the treatment area(s) on the face or scalp 1 time a day for 5 days in a row (consecutive) using 1 single dose packet with each application. Do not apply KLISYRI to other areas.
  • Do not use more KLISYRI than you need to cover the treatment area. Using too much KLISYRI, or using it too often, or for too long can increase your chances of having a severe skin reaction or other side effects.
  • Do not cover the treatment area with a dressing after application of KLISYRI. Irritation of the skin may happen if a dressing is applied to the treatment area.
  • Do not get KLISYRI in, around, or near your eyes. Do not touch your eyes while you are applying KLISYRI
    • Wash your hands right away with water and soap after applying KLISYRI. After applying KLISYRI, be careful to keep KLISYRI on the treated area from coming into contact with your eyes. Irritation may happen if you get KLISYRI in your eyes.
    • If you accidentally get KLISYRI in your eyes, flush them with water and get medical care as soon as possible. See, "What are the possible side effects of KLISYRI?"
  • Do not get KLISYRI in, around, or near your mouth or lips.
  • Avoid washing and touching the treated area for approximately 8 hours after application of KLISYRI. After 8 hours, you may wash the area with a mild soap and water.
  • Avoid transferring the product to other areas after application.
  • Throw away any open packet of KLISYRI after use even if there is medicine still left in it.

What are the possible side effects of KLISYRI?

KLISYRI may cause serious side effects, including:

  • Eye irritation can happen if KLISYRI gets into your eyes. If you accidentally get KLISYRI into your eyes, flush them with water and get medical care as soon as possible.
  • Local skin reactions are common but can also be severe during treatment with KLISYRI. Call your healthcare provider if you develop any local skin reactions including redness, flaking or scaling, crusting, or swelling that is more severe, or if you get blisters, peeling, pus, ulcers, or breakdown of your skin.

The most common side effects of KLISYRI include: itching or pain in the treatment area.

These are not all of the possible side effects of KLISYRI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Important Safety Information

Open ISI icon Close ISI icon

Important: KLISYRI is for use on the skin only (topical). Do not use KLISYRI in, around, or near your eyes, mouth or lips.

What is KLISYRI?

KLISYRI is a prescription medicine used on the skin to treat actinic keratosis on the face or scalp.
It is not known if KLISYRI is safe and effective in children less than 18 years of age.

Before using KLISYRI, tell your healthcare provider about all of your medical conditions, including if you:

  • are being treated or have been treated for actinic keratosis with any other medicine, procedure, or surgery. You should not use KLISYRI until your skin has healed from other treatments.
  • have other skin problems in the treatment area.
  • are pregnant or plan to become pregnant. It is not known if KLISYRI can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if KLISYRI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with KLISYRI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

How should I use KLISYRI?

  • Use KLISYRI as your healthcare provider tells you to. KLISYRI is for skin use only.
  • Apply KLISYRI to evenly cover the treatment area(s) on the face or scalp 1 time a day for 5 days in a row (consecutive) using 1 single dose packet with each application. Do not apply KLISYRI to other areas.
  • Do not use more KLISYRI than you need to cover the treatment area. Using too much KLISYRI, or using it too often, or for too long can increase your chances of having a severe skin reaction or other side effects.
  • Do not cover the treatment area with a dressing after application of KLISYRI. Irritation of the skin may happen if a dressing is applied to the treatment area.
  • Do not get KLISYRI in, around, or near your eyes. Do not touch your eyes while you are applying KLISYRI
    • Wash your hands right away with water and soap after applying KLISYRI. After applying KLISYRI, be careful to keep KLISYRI on the treated area from coming into contact with your eyes. Irritation may happen if you get KLISYRI in your eyes.
    • If you accidentally get KLISYRI in your eyes, flush them with water and get medical care as soon as possible. See, "What are the possible side effects of KLISYRI?"
  • Do not get KLISYRI in, around, or near your mouth or lips.
  • Avoid washing and touching the treated area for approximately 8 hours after application of KLISYRI. After 8 hours, you may wash the area with a mild soap and water.
  • Avoid transferring the product to other areas after application.
  • Throw away any open packet of KLISYRI after use even if there is medicine still left in it.

What are the possible side effects of KLISYRI?

KLISYRI may cause serious side effects, including:

  • Eye irritation can happen if KLISYRI gets into your eyes. If you accidentally get KLISYRI into your eyes, flush them with water and get medical care as soon as possible.
  • Local skin reactions are common but can also be severe during treatment with KLISYRI. Call your healthcare provider if you develop any local skin reactions including redness, flaking or scaling, crusting, or swelling that is more severe, or if you get blisters, peeling, pus, ulcers, or breakdown of your skin.

The most common side effects of KLISYRI include: itching or pain in the treatment area.

These are not all of the possible side effects of KLISYRI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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KLISYRI® is a registered trademark of Almirall, LLC. © Copyright 2005-2021. All Rights Reserved. Almirall, LLC, Exton, PA 19341 US-TIRBA-2100058 02/2021

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KLISYRI® is a registered trademark of Almirall, LLC. © Copyright 2005-2021. All Rights Reserved. Almirall, LLC, Exton, PA 19341 US-TIRBA-2100058 02/2021

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